Scientist, Biology

The Research department at Alnylam has an exciting opportunity available for a highly motivated research scientist to join our Next Wave biology group. Our mission is to identify new therapeutic siRNA targets across various tissue types to address disease areas with high unmet need and fuel the growing Alnylam pipeline. The position will be working in an interdisciplinary team, closely collaborating with the RNAi platform discovery, human genetics, biology and clinical teams to drive early-stage target discovery and validation work.

This is an on-site position located in Cambridge, MA.

Summary of Key Responsibilities

• Identify novel RNAi targets using human genetics, literature search and systems biology approaches
• Develop, design and execute in vitro and in vivo models to experimentally validate the candidate targets
• Analyze and present data at internal team meetings and stay abreast of relevant scientific literature
• Manage relationships with contract research organizations (CROs) and/or academic collaborators, including development of research plans and data analysis
• Work collaboratively across biology, human genetics and RNAi platform teams
• Mentor junior scientists

Qualifications

• PhD degree in biology or biomedical sciences-related fields, postgraduate experience of >3 years is a plus but not required
• Strong track records showing proficiency in characterization of in vitro, ex vivo and in vivo disease models (eg. human iPSC, primary cells, rodent models), with deep understanding of the underlying biological pathways
• Proficiency in molecular biology and biochemistry is a strong plus
• Demonstrate broad knowledge across areas of biology including physiology, metabolic pathways and human genetics is strongly desired. Background in immunology or neuroscience is a plus.
• The candidate must be flexible, able to adapt and apply his/her knowledge to new biological/therapeutic areas, thrive in a fast-paced team environment, and possess excellent communication skills (both written and oral).
• Prior experience in industry is a plus but not required.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.