Research Fellow

Research Fellow in Molecular Biology with a Focus on Aging and Metabolism

Job Summary:
The Manstein Laboratory at Massachusetts General Hospital is conducting research in dermatology, focusing on the development of novel, energy-based procedures for the treatment of various skin conditions, including scars, burns, aging, and fat removal. We are expanding our research scope to include the molecular mechanisms underlying aging, energy homeostasis, adipogenesis, and the biochemical basis of metabolic diseases. We seek a Research Fellow with a strong background in Molecular Biology and Immunology, specifically with expertise in aging, energy balance, tissue development, and the pathogenesis of metabolic diseases, including obesity. This role involves designing and conducting experiments, analyzing data, and contributing to our understanding of these conditions to identify novel therapeutic targets.

Responsibilities:

• Lead research projects investigating the molecular and biochemical pathways involved in aging, energy homeostasis, adipogenesis, and metabolic diseases.
• Utilize advanced molecular biology techniques to explore tissue development processes and their dysregulation in metabolic diseases.
• Develop and implement in vitro and in vivo models to study laser effects on the pathogenesis of obesity.
• Analyze genetic, epigenetic, and environmental factors contributing to metabolic disorders, employing genomic, proteomic, and metabolomic technologies.
• Collaborate with a multidisciplinary team to integrate findings from molecular studies with clinical insights, aiming to translate research outcomes into innovative therapeutic approaches.
• Stay informed about the latest scientific advancements in molecular biology, aging research, and metabolic disease therapeutics.
• Contribute to the writing and submitting of research manuscripts for publication and prepare grant proposals to secure funding.
• Present findings at national and international scientific meetings and participate in scientific community exchanges.

Requirements:

• A Ph.D. in Molecular Biology or Biochemistry with deep knowledge in immunology or a closely related field focusing on aging, adipogenesis, and metabolic diseases.
• Demonstrated expertise in molecular biology techniques and experience with tissue culture and molecular assays relevant to studying metabolic pathways.
• Strong foundation in studying aging, energy balance, and the molecular basis of metabolic diseases, including obesity.
• Experience with animal models of metabolic diseases and familiarity with metabolic assays.
• Proven track record of scientific publications in high-impact journals.
• Excellent written and verbal communication skills, with the ability to work independently and collaboratively in a multidisciplinary research environment.

Preferred Qualifications:

• Experience with next-generation sequencing, bioinformatics, and data analysis techniques.
• Background in dermatological research or a strong interest in exploring the skin as a model system for studying metabolic diseases.
• Demonstrated ability to innovate, with a passion for solving complex problems in metabolic disease research.

Position Details:

This is a full-time role offering a competitive salary (above NIH post doc stipend levels) and benefits package, matching experience, and qualifications. Located within the research community of Massachusetts General Hospital/Harvard Medical School, the Manstein Lab provides an exceptional environment for scientific growth and discovery.

Candidates passionate about advancing the field of molecular biology with a focus on aging, energy homeostasis, and metabolic diseases and eager to contribute to the development of medical solutions are encouraged to apply. Please submit your application, including a resume and a cover letter outlining your relevant experiences and interests.

Applications will be reviewed on a rolling basis until the position is filled. We thank all applicants for their interest; however, only those selected for an interview will be contacted.

Project Description:

Building on our findings with large area fractional laser treatment (LAFLT) and its significant metabolic effects, our next project aims to deepen our understanding by exploring the broader molecular and systemic impacts of LAFLT, with a particular focus on aging and energy homeostasis. This research will extend beyond the metabolic parameters to investigate how LAFLT influences aging processes, modulating energy homeostasis and the immune response at a cellular level to potentially improve tissue function and longevity. By integrating various advanced molecular techniques and systemic analyses, including gene expression profiling, epigenetic markers of aging, and assessments of mitochondrial function, we will elucidate the mechanisms through which LAFLT affects not only metabolism but also the broader physiological landscape. This project promises to uncover novel insights into the potential of LAFLT as a multifaceted therapeutic approach, potentially offering new avenues for treating aging-related diseases, optimizing energy balance, and enhancing overall health.

Previous Publications:
https://www.sciencedirect.com/science/article/pii/S2589004223027542