Postdoctoral Fellow - Dalton Cardiovascular Research Center

Department of Medical Pharmacology and Physiology

A postdoctoral fellow position within the Dalton Cardiovascular Research Center at University of Missouri to study the role of super enhancers in coordinating intercellular and interorgan communications in cardiovascular disease. We mainly focus on cardiac maladaptive remodeling and dysfunction in diverse pathological settings, such as pressure overload, myocardial infarction, obesity, and diabetes, as well as vein graft failure, arteriovenous fistula failure, and cardiac allograft vasculopathy. This research will involve the formulation and testing of hypotheses utilizing animal models, primary cultures of cardiovascular cells, molecular and cell biology techniques, and imaging techniques. The postdoctoral fellows will be expected to be current in biological science, to plan and conduct experiments, interpret data, and publish results. Successful candidates will have a significant record of accomplishment that demonstrates creativity and initiative and will be working as a team closely with the PI in his well-equipped state of the-art research lab. Preference will be given to recently graduated candidates with strong career motivation.

Job Responsibilities:
* Conduct active lab research on a semi-independent basis at the beginning and on an independent basis afterwards. The lab research work includes, but not limited to, cardiovascular cell culture, molecular and cellular biology techniques such as Western blot, PCR, gene knockdown and overexpression, RNA-seq, ATAC-seq, scRNA-seq, Spatial Transcriptomics, and microscopic imaging, as well as echocardiography, and animal care and animal models such as transverse aortic arch constriction (TAC), myocardial infarction, heart transplantation, carotid artery ligation, and vein graft transplantation. In addition, it includes mouse crossbreeding to generate mice with conditional gene knockout and overexpression specific in cardiovascular cells as well as the cell lineage fate mapping of cardiovascular cells.
* Design and evaluate experiments; develop new ideas that promote current research.
* Train and oversee technicians as determined by PI.
* Hold responsibility for operation of specific equipment if needed.
* Prepare and publish scientific manuscripts under the direction of the PI.
* Perform other duties as assigned or requested by PI.

Education: Ph.D., M.D. or equivalent from an accredited institution in any field of biochemistry, biology, pharmacology, and medicine.

Candidates will be evaluated on: highly motivated, have scientific independence, excellent English speaking and writing skills, and international peer-reviewed publications. Practical experience with molecular and cellular biology techniques, such as tissue cultures, genetic manipulation (knock down, knockout, and overexpression), and single-cell multiomics is required. Experiences in cardiac or vascular biology/physiology research and creating mouse models of cardiovascular diseases, such as TAC model, myocardial infarction, vein graft transplantation or arteriovenous fistula are highly preferred. Experience in multiomics data analysis will be a plus.

Applicants should submit their curriculum vitae, cover letter with description of current research.

This position is eligible for University benefits. The University offers a comprehensive benefits package, including medical, dental and vision plans, retirement, and educational fee discounts. For additional information on University benefits, please visit the Faculty & Staff Benefits website at http://www.umsystem.edu/totalrewards/benefits

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