Post-Doctoral Fellow

Job Summary:

The Department of Pediatrics at the University of Colorado Anschutz is looking for a post-doctoral fellow to join our lab (diaslab.org). The fellow will be responsible for driving an independent project studying neurodegeneration using human cells and tissues. Model systems and techniques include using post-mortem brain tissue and human cell lines, as well as long read and single cell sequencing. Experience and/or comfort with these paradigms are a critical component of this role. The goal of the research project broadly is to better understand essential mechanisms underlying the disorder Fragile X-associated tremor/ataxia syndrome, a neurodegenerative disorder associated with cognitive decline, psychiatric co-morbidities, and tremor and ataxia. Our lab affords a collaborative mind-set and opportunities for professional development and growth for those with a variety of career aspirations. Former and current lab members have been highly successful in publishing, obtaining fellowships, and pursuing long-term professional goals.

Key Responsibilities:

• Developing testable hypotheses and conducting molecular biology experiments and analyses including but not limited to high molecular weight DNA extraction & sequencing, RNA expression/studies, single-cell -omics experiments, in situ studies, and cell culture work
• Analyzing sequencing data including long read DNA sequencing, bulk RNA-seq, and single-nucleus RNA/ATAC using R, python, command line interface and high-performance computing clusters
• Thorough documentation and communication of experiments and findings with lab notebook, appropriate version control
• Presentations expected at lab meetings, and at regional and national conferences
• Supervision of more junior laboratory members

Work Location:

Onsite - this role is expected to work onsite and is located in Aurora, CO.

Why Join Us:

With an abundance of sunshine and mountains nearby, the Colorado Front Range is the place to be! The University of Colorado Anschutz Medical Campus ranks among the top 20 medical centers in the country. CU Anschutz has top ranked clinical programs in family medicine and pediatrics, and the basic science and applied health research programs attract more NIH funding than any other university in Colorado. CU-Anschutz is home to the University of Colorado Hospital, The Children's Hospital of Colorado, and the University of Colorado Schools of Medicine, Nursing, Dentistry, Pharmacy and Pharmaceutical Sciences, and Public Health, providing access to an array of possibilities to improve lives across a spectrum of ages and disease states.

The University of Colorado offers a comprehensive benefits package. To see what benefits are available for Post-Doctoral Fellows, please visit:

Payroll & Benefits Orientation for Post-Doctoral Fellows | University of Colorado (cu.edu)

benefits guide cover-post-doc-2024 (cu.edu)

Qualifications:

Minimum Qualifications:

Applicants must meet minimum qualifications at the time of hire.

* PhD in Neuroscience, Human Genetics, Developmental Neurobiology, Molecular Biology or related field

* One (1) year experience working with post-mortem brain tissue or equivalent (other primary human tissue/cell work, and/or using BSL2 or greater precautions)

* One (1) year experience with hIPSC-derived cell culture or equivalent (human lines such as fibroblasts, lymphoblasts) and cell culture sterile technique

Condition of Employment:

• Applicants must be legally authorized to work in the United States without requiring sponsorship. We are unable to provide work visa sponsorship or employment authorization for this position now or in the future.

• Must successfully pass a drug test through Children's Hospital Colorado

• Must be willing and able to pass a national criminal background check

*For questions regarding Children's Hospital drug testing requirements, please contact Children's Human Resources at 720-777-8598. Some positions may require testing if access to Children's Hospital or their systems is needed at any time during employment with the University. If drug testing is required, it will be listed in the job posting.

Preferred Qualifications:

• One (1) year experience with R, python, or equivalent analysis of sequencing data such as long-read or single-cell RNA and DNA methods

• Two to five (2-5) years of experience working with post-mortem brain tissue or equivalent (other primary human tissue/cell work, and/or using BSL2 or greater precautions)

• Two to five (2-5) years of experience with hIPSC-derived cell culture or equivalent (human lines such as fibroblasts, lymphoblasts) and cell culture sterile technique

Knowledge, Skills and Abilities:

* Working knowledge of common molecular biology techniques such as qPCR, IHC, protein extraction and assessment, sterile cell culture, cloning, etc

* Ability to clearly document experiments and analyses

* Ability to work collaboratively & professionally

* Ability to independently trouble-shoot experiments and learn new techniques

* Demonstrated productivity with respect to:

o prior publications

o competitive prior and/or current funding/travel awards/fellowships

o oral presentation at regional and national levels

How to Apply:

For full consideration, please submit the following document(s):

1. A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position

2. Curriculum vitae / Resume

3. Five professional references including name, address, phone number (mobile number if appropriate), and email address

Applications are accepted electronically ONLY at www.cu.edu/cu-careers.

Questions should be directed to: Caroline.dias@cuanschutz.edu

Screening of Applications Begins:

Immediately and continues until position is filled. For best consideration, apply by 7/30.

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as HIRING RANGE:

0 years of experience: $63,480 - $66,700

1 year of experience: $63,900 - $67,200

2 years of experience: $64,380 - $67,800

3 years of experience: $66,948 - $70,500

4 years of experience: $69,180 - $72,800

The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator: http://www.cu.edu/node/153125

Equal Employment Opportunity Statement:

The University of Colorado (CU) is an Equal Opportunity Employer and complies with all applicable federal, state, and local laws governing nondiscrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity, and we encourage individuals from all backgrounds to apply, including protected veterans and individuals with disabilities.

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@ucdenver.edu.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program.