Scientist III - Non-Viral CAR-T/Nanomedicine

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Genentech San Diego's Department of Genetic Medicine Technology is seeking a highly motivated and skilled Scientist III to join the Nanotechnology Platform Group. This role is pivotal in accelerating our internal programs. The successful candidate will possess expertise in molecular biology and gene delivery, with hands-on experience in the design, manipulation, and functional assessment of nucleic acids delivered via lipid nanoparticles (LNPs) for T-cell engineering.

Key Responsibilities

• Design and execute complex functional T-cell assays (in vitro cytotoxicity, proliferation, and cytokine profiling).

• Develop and run advanced, multi-parameter flow cytometry panels for rigorous analysis of T-cell phenotype, viability, and CAR or reporter protein expression levels.

• Execute molecular biology techniques including cloning, PCR/qPCR/ddPCR, sequencing analysis, in addition to routine examination of protein expression.

• Design, clone, and validate novel mRNA and plasmid DNA payloads optimized for maximal transient or stable expression in T cells, in vivo.

• Contribute to the development of intellectual property around novel nucleic acid delivery platforms.

• Execute LNP preparation and characterization workflows for both mRNA and pDNA payloads.

• Plan and execute in vivo studies in relevant mouse models to assess efficacy, persistence, and biodistribution of LNP-delivered constructs.

Required Qualifications (must-haves)

• M.S. in Molecular Biology, Immunology, Bioengineering, or pharmaceutical science with 6+ years of industry experience or Ph.D. with 0-2 years relevant experience in academic or industry setting.

• T-Cell Experience: Extensive experience with isolation, culture, expansion, and functional assessment of primary human and murine T-cells.

• Flow Cytometry Mastery: Proven hands-on experience in panel design and advanced data analysis (e.g., FlowJo).

• Molecular Biology: Fluency in molecular cloning, sequence analysis, DNA/RNA manipulation, and methods to assess protein expression (e.g. western blotting).

Preferred/Growth Skills

• Prior experience in designing and executing antibody optimization, expression, and purification is preferred but not required

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of San Diego, CA is $89,900 - $166,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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