Associate Staff Scientist

Closing Date:

The University of Arkansas for Medical Sciences (UAMS) has a unique combination of education, research, and clinical programs that encourages and supports teamwork and diversity. We champion being a collaborative health care organization, focused on improving patient care and the lives of Arkansans.

UAMS offers amazing benefits and perks (available for benefits eligible positions only):

• Health: Medical, Dental and Vision plans available for qualifying staff and family
• Holiday, Vacation and Sick Leave
• Education discount for staff and dependents (undergraduate only)
• Retirement: Up to 10% matched contribution from UAMS
• Basic Life Insurance up to $50,000
• Career Training and Educational Opportunities
• Merchant Discounts
• Concierge prescription delivery on the main campus when using UAMS pharmacy

Below you will find the details for the position including any supplementary documentation and questions you should review before applying for the opening. To apply for the position, please click the Apply link/button.

Persons must have proof of legal authority to work in the United States on the first day of employment.

All application information is subject to public disclosure under the Arkansas Freedom of Information Act.

For general application assistance or if you have questions about a job posting, please contact Human Resources at askrecruitment@uams.edu.

Department's Website:

• Ph.D. in Bioscience, Biochemistry, Structural Biology, or a related PLUS five (5) years of laboratory experience in structural biology, including both X-ray crystallography and cryo-EM

• Demonstrated expertise in "gene-to-structure" determination, including protein expression, purification, crystallization, and structure analysis

• Proven record of successful cryo-EM structure determination supported by peer-reviewed publications or scientific presentations

• Experience with bacterial protein expression and purification

Knowledge, Skills, and Abilities:

• Proficiency with structural biology software such as RELION, CryoSPARC, Phenix, CCP4, and Coot

• Strong understanding of protein biochemistry, molecular biology, and macromolecular structure-function relationships

• Experience with Linux-based computational environments for data analysis and modeling

• Ability to troubleshoot complex experimental and computational workflows

• Excellent organizational, communication, and documentation skills

• Demonstrated ability to work both independently and collaboratively in a multidisciplinary research setting

• Commitment to maintaining safety, data integrity, and scientific rigor in all laboratory activities

Preferred Qualifications:

• Experience expressing and purifying proteins using mammalian, yeast, or insect cell systems

• Experience assisting and mentoring scientists in structure determination by cryo-EM and/or X-ray crystallography

• Strong collaborative and problem-solving skills

This position is a Designated Research Position and involves scientific investigation or development that involves technologies, designs, or technical data considered sensitive enough to potentially impact national security and therefore requires strict controls on export or transfer to foreign entities. The Arkansas Research & Education Protection Act of 2025 requires the University to obtain additional information about your background for this Research Position.

Additional Information:

Responsibilities:

• Conduct structural biology research using cryo-electron microscopy (cryo-EM) and X-ray crystallography.

• Prepare and freeze grids, evaluate samples by negative stain and cryo-EM, and collect high-resolution cryo-EM data.

• Perform particle selection, classification, and structure refinement to determine and finalize coordinate structures.

• Conduct crystallization screening, crystal optimization, X-ray diffraction data collection, structure solution, and refinement.

• Prepare and purify samples for analysis by cryo-EM and X-ray crystallography.

• Train students, postdoctoral fellows, and scientists in structural biology techniques.

• Supervise laboratory staff and ensure compliance with all University, State, and Federal safety regulations.

• Maintain and operate laboratory equipment including FEI Vitrobot, Leica GP2, Mosquito crystallization robot, and Formulatrix plate hotel.

• Manage inventory, order supplies, and track equipment service and maintenance schedules.

• Supervise and support personnel in developing new laboratory protocols.

• Collaborate with faculty, students, and postdoctoral fellows to advance research projects.

• Work independently while maintaining consistent communication with the Principal Investigator.

• Perform additional duties as assigned.

Salary Information:

Required Documents to Apply:

Please contact askrecruitment@uams.edufor any recruiting relatedquestions.

All application materials must be uploaded to the University of Arkansas System Career Sitehttps://uasys.wd5.myworkdayjobs.com/UASYS

Please do not send to listed recruitment contact.

This position is subject to pre-employment screening (criminal background, drug testing, and/or education verification). A criminal conviction or arrest pending adjudication alone shall not disqualify an applicant except as provided by law. Any criminal history will be evaluated in relationship to job responsibilities and business necessity. The information obtained in these reports will be used in a confidential, non-discriminatory manner consistent with state and federal law.