Director of Computational Sciences

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Thomas lab in the Vaccine and Infectious Disease Division is seeking a Director of Computational Sciences to lead a program in immune repertoire profiling, decoding, and analysis.

The individual will manage multiple individuals at various ranks, providing support a) sample selection and study design, b) experimental protocols for data generation, and c) data analysis specifically for lymphocyte TCR and BCR repertoire sequencing. Studies will be focused on primary human samples derived from blood or tissues in individuals with characterized infection or tumor histories. Using a combination of bioinformatic and computational approaches, we will integrate these data with other data and metadata obtained from the sample and individuals, including tumor mutation profiles, infection histories, serology, and other high resolution immune profiling. In addition to these core objectives, we will include analysis of valuable and clinically relevant sample sets such as HCT patients experiencing GVH, and aplastic anemia subjects.

This position leads an interdisciplinary project team to develop and optimize novel TCR/BCR repertoire sequencing technologies and data analysis strategies.

Lead and manage the interdisciplinary team of scientists focused on immune repertoire decoding and analysis.
• Propose innovative technologies and processes for immune profiling of intra-tumoral lymphocytes, tissue lymphocytes, and other primary samples from diverse human disease states and oversee development, implementation and adoption of these technologies by the project team.
• Collaborate with key leaders at Fred Hutch to ensure project success.
• Oversee systems of governance, monitoring, review and control processes in the repertoire profiling efforts of the lab.
• Manage the overall budget, interaction with vendors and equipment purchase.
• Direct team management processes, including goal setting, performance, development and engagement.
• Other duties as assigned.

MINIMUM QUALIFICATIONS:

• PhD in life science or computational biology field.
• 10+ years of experience in immune repertoire analysis, strong publication record, experience in managing mid-large teams on data science projects/processes.
• Extensive experience in adaptive immune receptor repertoire data analysis.
• Driven individual capable of creative independent research, as demonstrated by first author publication(s) and presentations.
• Exceptional multi-tasking and project management skills.
• Superior written communication skills, as demonstrated by successful applications for external funding.
• Extensive experience in immune repertoire data analysis, bioinformatics algorithms and software development.
• Deep understanding of molecular biology protocols for TCR/BCR library preparation and sequencing.

The annual base salary range for this position is from $94,037 to $212,035, and pay offered will be based on experience and qualifications.

This position may be eligible for relocation assistance.

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (up to 13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 12 months for professor track faculty, up to 6 months for other scientific staff).