New

Bioinformatician I

Massachusetts General Hospital
United States, Massachusetts, Boston
149 13th Street (Show on map)
Jul 25, 2025
The Iafrate Lab in the MGH Molecular Pathology Unit is seeking a highly motivated Bioinformatics Scientist to join our research team. This position will focus on genomic and transcriptomic data analysis. The successful candidate will work closely with biologists, computational scientists, and clinicians to extract meaningful insights from multimodal datasets. Key Responsibilities 1. Genomic & Transcriptomic Data Analysis Perform bulk RNA-seq, single-cell RNA-seq (scRNA-seq), and spatial transcriptomics data analysis Conduct Next-Generation Sequencing (NGS) analysis, including variant calling, gene expression analysis, and pathway enrichment studies Utilize bioinformatics pipelines (e.g., STAR, Cell Ranger, Seurat, DESeq2, Monocle, Scanpy) for data processing and interpretation Work with long-read sequencing (PacBio, Oxford Nanopore) and epigenomics as needed 2. Data Management & Computational Infrastructure Develop and maintain data pipelines for sequencing datasets Manage data storage, versioning, and retrieval in compliance with FAIR data principles Maintain documentation and reproducible workflows using Snakemake, Nextflow, or WDL Required Skills & Qualifications PhD (or MSc with equivalent experience) in Bioinformatics, Computational Biology, Biostatistics, or related field * Strong proficiency in Python, R and RStudio, and Bash scripting * Expertise in NGS data processing and analysis, including RNA-seq, scRNA-seq, and variant analysis * Familiarity with data visualization tools (Shiny, Dash, ggplot2, Matplotlib) * Experience working in Unix/Linux environments and using HPC/cloud-based pipelines * Experience writing code using good programming principles (refactoring, unit testing, version control) * Strong organizational skills for handling large and complex datasets * Ability to collaborate effectively in a multidisciplinary research team * Excellent oral and written communication skills Preferred Skills * Knowledge of spatial transcriptomics technologies (e.g., Visium, CosMx, MERSCOPE) * Familiarity with Linux system administration with networking * Familiarity with database management (SQL) * Familiarity with machine learning / AI for genomic data analysis Physical Requirements Standing Occasionally (3-33%) Walking Occasionally (3-33%) Sitting Constantly (67-100%) Lifting Occasionally (3-33%) 20lbs - 35lbs Carrying Occasionally (3-33%) 20lbs - 35lbs Pushing Rarely (Less than 2%) Pulling Rarely (Less than 2%) Climbing Rarely (Less than 2%) Balancing Occasionally (3-33%) Stooping Occasionally (3-33%) Kneeling Rarely (Less than 2%) Crouching Rarely (Less than 2%) Crawling Rarely (Less than 2%) Reaching Occasionally (3-33%) Gross Manipulation (Handling) Constantly (67-100%) Fine Manipulation (Fingering) Frequently (34-66%) Feeling Constantly (67-100%) Foot Use Rarely (Less than 2%) Vision - Far Constantly (67-100%) Vision - Near Constantly (67-100%) Talking Constantly (67-100%) Hearing Constantly (67-100%) The General Hospital Corporation is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.