SRA 1/2
Job Summary The anticipated duration of this temporary assignment is approximately 8 months
In the Staff Research Associate position you would be a key team member of the Mordes lab at the UCSF Institute for Neurodegenerative Diseases (IND). The Mordes lab integrates novel human stem cell-based models with neuropathology to understand disease mechanisms for dementia, ALS, Parkinson's disease and related neurodegenerative diseases to guide the development of new treatment strategies. We routinely differentiate pluripotent stem cells to excitatory neurons and spinal motor neurons to examine cellular pathways that have been implicated in disease by unbiased human genetic studies. Our group in part of the Institute for Neurodegenerative Diseases and the Weill Institute for Neuroscience at UCSF and we collaborate with several groups at UCSF and in biotech for multi-omic approaches. We are a young vibrant group of investigators and support the scientific pursuits and career development of each other.
In this position, you will be working as a member of a research team that examines how neurons maintain protein and RNA homeostasis and investigate disease mechanisms that are associated with both familial and sporadic forms of age-related neurodegeneration. For our lab environment, we seek lab members with strong communication skills and organizational that are passionate to advance our knowledge of the brain with the goal of finding new ways to treat progressive neurological diseases. The projects will be guided by the principal investigator and post-doctoral fellows. Routine lab experiments and operations are expected to be independent. Depending on experience and interests, there may be an opportunity for "dry lab" computational based biological studies as well. Prior lab members have contributed to publications and pursue medical school or graduate school program.
Responsibilities include tissue culture-based experiments with stem cells, neurons, and glia as well as molecular biology methods including protein-based assays, molecular cloning, qPCR, imaging, preparation of nucleic acid libraries, cell imaging imaging, and standard statistical analysis. Additional duties may include preparing shared lab reagents, occasionally ordering lab supplies based on kab inventory, and other lab duties as assigned. There may be a minor component, no more than 25% of effort, of animal husbandry and working with murine models and examining brain and spinal cords.
Key Responsibilities:
- Tissue culture and directed differentiation of human stem cells, collection of cells and neurons and downstream analysis including immunoblots, immunostaining, and qPCR
- Additional molecular biology and biochemical methods
- Routine lab preparations and maintainenace of lab supplies, solutions, and standard equipment
- Animal husbandry and working with murine models of disease in the vivarium
The final salary and offer components are subject to additional approvals based on UC policy. To see the salary range for this position (we recommend that you make a note of the job code and use that to look up): TCS Non-Academic Titles Search (https://tcs.ucop.edu/non-academic-titles) Please note: An offer will take into consideration the experience of the final candidate AND the current salary level of individuals working at UCSF in a similar role. For roles covered by a bargaining unit agreement, there will be specific rules about where a new hire would be placed on the range. To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html Department Description UCSF's Temporary Employment Program (TEP) recruits and hires temporary employees for immediate clerical and technical support services to UCSF Departments and various off-campus locations. UCSF departments deploy temporary employees to work on special projects, fill in for regular employees who are on vacation or leave, or to temporarily fill a vacant position during recruitment. Frequently temporary employees become successful candidates for career and limited appointment positions. Required Qualifications SRA I:
- B.A/B.S. degree in molecular cell biology or related field science and knowledge of, or experience with, the basic techniques or methods required by the position; or an equivalent combination of education and experience
- Working knowledge of MS Office (Word, Excel, PowerPoint)
- Highly organized, attention to detail, demonstrated record-keeping abilities
- Excellent communication skills; good written English and skills to write reports
SRA 2: In addition to above,
- One or more years of recent, directly related work experience following degree completion, utilizing the techniques or methods required by the position; or an equivalent combination of education and experience.
Preferred Qualifications
- Experience with pluripotent stem cell culture
- Expereience in primary or human (iPSC-derived) neuron culture
- Experience in molecular biology, such as PCR or molecular cloning
- Experience in biochemistry, such as Western blotting, immunoprecipitation, or enzymatic assays
- Working knowledge of flow cytometry and microscopy
- Bioinformatics experience, such as analysis of imaging or next-generation sequencing data
- Experience culturing mammalian cells, with demonstrated proficiency in sterile technique
- Animal husbandry and working with murine models of disease
About UCSF The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world's leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells. Pride Values UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence - also known as our PRIDE values.
In addition to our PRIDE values, UCSF is committed to equity - both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at diversity.ucsf.edu
Join us to find a rewarding career contributing to improving healthcare worldwide. Equal Employment Opportunity The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Job Code and Payroll Title 009613 SRA 1 Job Category Research and Scientific, Temporary Employment Bargaining Unit University Professional Technical Employees - Research Support Professionals Unit (UPTE-RX) Employee Class Temporary Employment Location San Francisco, CA Additional Shift Details 40 hours/week |
University of California - San Francisco Campus and Health
Mar 11, 2025