Research Professional or Lead, Spinal Development and Disease

Job Summary:

The Burger laboratory in the Colorado Program for Musculoskeletal Research, within the Department of Orthopedics, is seeking to fill the position of a Research Professional or Lead for research relating to vertebrate notochord and intervertebral disc development and disease. In the Burger lab, we are interested in early vertebrate development of the axial and lateral plate mesoderm using zebrafish and mice as models, as well as associated structural birth defects, such as spina bifida, or defects affecting the heart/blood/bone/kidney. We are further interested in how the axial mesoderm develops into the intervertebral discs, and associated underlying molecular mechanisms, as well as intervertebral disc disease, such as IVD degeneration. This position is expected to be the research lead for several ongoing projects, including design of experimental setup, data generation, and data interpretation.

Key Responsibilities:

• Conducting molecular biology experiments, such as, but not limited to: PCR, gateway cloning, restriction digest and T4 ligation, Sanger sequencing of plasmid vectors, RNA work, e.g. CRISPR guide RNA generation, mRNA generation, immunohistochemistry/fluorescence, Western blotting, RNA and genomic DNA collection from mouse for RNAseq and ATACseq experiments
• Work with different mouse mutant and transgenic strains, such as mouse husbandry/breeding, genotyping, dissection for tissue collection, e.g. spine, long bones, etc.
• Mouse skeletal and non-skeletal tissue harvest for histological analysis, including embedding, sectioning and imaging, and for RNA and genomic DNA preparation
• Ordering consumables and materials, etc.
• Maintaining laboratory area and equipment in working and clean condition
• Contributing to animal protocol writing
• Handling EHS requirements

Work Location:

Onsite - this role is expected to work onsite and is located in Aurora, CO.

Why Join Us:

The University of Colorado School of Medicine's Department of Orthopedics is dedicated to advancing orthopedic care through a comprehensive approach that encompasses education, research, and patient care. Comprising a team of renowned orthopedic surgeons, researchers, and educators, the department is committed to excellence in all facets of its mission. From providing cutting-edge educational programs and clinical services to conducting groundbreaking research initiatives, the Department of Orthopedics at the University of Colorado School of Medicine plays a pivotal role in shaping the future of musculoskeletal health. With a focus on innovation, community outreach, and the highest standards of quality, the department stands as a leader in the field, contributing to the well-being of individuals and the advancement of orthopedic knowledge.

The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off - vacation, sick, and holidays and more. To see what benefits are available, please visit: https://www.cu.edu/employee-services/benefits-wellness.

Diversity and Equity:

The University of Colorado Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty, and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities, persons within the LGBTQ+ community and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

Qualifications:

Minimum Qualifications:

Intermediate level:

• Bachelor's degree in biology, molecular biology, chemistry, genetics or related field
  
  
  
  • A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis
  
  
  
  
• One (1) year professional level wet lab research experience, including mouse work

Senior level:

• Bachelor's degree in biology, molecular biology, chemistry, genetics or related field
  
  
  
  • A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis
  
  
  
  
• Two (2) years professional level wet lab research experience, including mouse work

Principal level:

• Bachelor's degree in biology, molecular biology, chemistry, genetics or related field
  
  
  
  • A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis
  
  
  
  
• Three (3) years professional level wet lab research experience, including mouse work

Preferred Qualifications:

• Master's degree in biology, molecular biology, chemistry, genetics or related field
• Four (4) years of experience in an experimental or wet laboratory, including mouse work
• Prior experience with molecular biology methods including, but not limited to PCR, cloning, immunoprecipitation, microscopy, RNA in situ hybridization, etc.

Knowledge, Skills, and Abilities:

• Expert knowledge of laboratory techniques including safety procedures and techniques
• Expert ability to analyze and solve complex problems
• Ability to communicate effectively, both in writing and orally
• Ability to establish and maintain effective working relationships with employees at all levels throughout the institution
• Outstanding customer service skills
• Demonstrated commitment and leadership ability to advance diversity and inclusion
• Knowledge of basic human anatomy, physiology medical terminology
• Ability to interpret and master complex research protocol information
• {SME} Expert level knowledge of mouse work and development of the spine

How to Apply:

For full consideration, please submit the following document(s):

1. A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position

2. Curriculum vitae / Resume

3. Three to five professional references including name, address, phone number (mobile number if appropriate), and email address

Screening of Applications Begins:

Screening begins immediately and until position is filled.

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as

Intermediate: $48,970-$62,290

Senior: $52,941-$67,341

Principal: $60,882-$77,442

The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting. This position may be eligible for overtime compensation depending on the level.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator: http://www.cu.edu/node/153125

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@cuanschutz.edu.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students, and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program.